Regional patterns and association between obesity and hypertension in Africa: Evidence from the H3Africa Chair study

Onoja M. Akpa, Felix Made, Akinlolu Ojo, Bruce Ovbiagele, Dwomoa Adu, Ayesha A. Motala, Bongani M. Mayosi, Sally N. Adebamowo, Mark E. Engel, Bamidele Tayo, Charles Rotimi, Babatunde Salako, Rufus Akinyemi, Mulugeta Gebregziabher, Fred Sarfo, Kolawole Wahab, Godfred Agongo, Marianne Alberts, Stuart A. Ali, Gershim AsikiRomuald P. Boua, F. Xavier Gómez-Olivé, Felistas Mashinya, Lisa Micklesfield, Shukri F. Mohamed, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Stephen Tollman, Rulan S. Parekh, Chishala Chishala, Kenneth Ekoru, Salina P. Waddy, Emmanuel Peprah, George A. Mensah, Ken Wiley, Jennifer Troyer, Michèle Ramsay, Mayowa O. Owolabi

Research output: Contribution to journalArticlepeer-review

Abstract

Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns and association of obesity with hypertension among 30 044 continental Africans. We harmonized data on hypertension (defined as previous diagnosis/use of antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) and obesity from 30 044 individuals in the Cardiovascular H3Africa Innovation Resource across 13 African countries. We analyzed data from population-based controls and the Entire Harmonized Dataset. Age-adjusted and crude proportions of hypertension were compared regionally, across sex, and between hypertension definitions. Logit generalized estimating equation was used to determine the independent association of obesity with hypertension (P value <5%). Participants were 56% women; with mean age 48.5±12.0 years. Crude proportions of hypertension (at BP≥140/90 mmHg) were 47.9% (95% CI, 47.4–48.5) for Entire Harmonized Dataset and 42.0% (41.1–42.7) for population-based controls and were significantly higher for the 130/80 mm Hg threshold at 59.3% (58.7–59.9) in population-based controls. The age-adjusted proportion of hypertension at BP≥140/90 mmHg was the highest among men (33.8% [32.1–35.6]), in western Africa (34.7% [33.3–36.2]), and in obese individuals (43.6%; 40.3–47.2). Obesity was independently associated with hypertension in population-based controls (adjusted odds ratio, 2.5 [2.3–2.7]) and odds of hypertension in obesity increased with increasing age from 2.0 (1.7–2.3) in younger age to 8.8 (7.4–10.3) in older age. Hypertension is common across multiple countries in Africa with 11.9% to 51.7% having BP≥140/90 mmHg and 39.5% to 69.4% with BP≥130/80 mmHg. Obese Africans were more than twice as likely to be hypertensive and the odds increased with increasing age.

Original languageEnglish (US)
Pages (from-to)1167-1178
Number of pages12
JournalHypertension
DOIs
StateAccepted/In press - 2020

Keywords

  • Africa
  • Blood pressure
  • Hypertension
  • Obesity
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine

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