Regulated nucleosome mobility and the histone code

Michael S. Cosgrove, Jef D. Boeke, Cynthia Wolberger

Research output: Contribution to journalReview articlepeer-review


Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

Original languageEnglish (US)
Pages (from-to)1037-1043
Number of pages7
JournalNature Structural and Molecular Biology
Issue number11
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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