Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.
|Original language||English (US)|
|Number of pages||7|
|Journal||Nature Structural and Molecular Biology|
|State||Published - Nov 2004|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology