Regulated nucleosome mobility and the histone code

Michael S. Cosgrove, Jef D. Boeke, Cynthia Wolberger

    Research output: Contribution to journalReview articlepeer-review


    Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

    Original languageEnglish (US)
    Pages (from-to)1037-1043
    Number of pages7
    JournalNature Structural and Molecular Biology
    Issue number11
    StatePublished - Nov 2004

    ASJC Scopus subject areas

    • Structural Biology
    • Molecular Biology


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