Regulation of chromatin architecture by protein binding: insights from molecular modeling

Stephanie Portillo-Ledesma, Tamar Schlick

Research output: Contribution to journalReview articlepeer-review


Histone and non-histone proteins play key roles in the activation and repression of genes. In addition to experimental studies of their regulation of gene expression, molecular modeling at the nucleosome, chromatin, and chromosome levels can contribute insights into the molecular mechanisms involved. In this review, we provide an overview for protein-bound chromatin modeling, and describe how our group has integrated protein binding into genome systems across the scales, from all-atom to coarse-grained models, using explicit to implicit descriptions. We describe the associated applications to protein binding effects and biological mechanisms of genome folding and gene regulation. We end by illustrating the application of machine learning tools like AlphaFold2 to proteins relevant to chromatin systems.

Original languageEnglish (US)
JournalBiophysical Reviews
StateAccepted/In press - 2024


  • Chromatin
  • Chromosome
  • Histone and non-histone proteins
  • Molecular modeling
  • Nucleosome

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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