Regulation of inhibitory synapse function in the developing auditory CNS

Dan H. Sanes, Emma C. Sarro, Anne E. Takesian, Chiye Aoki, Vibhakar C. Kotak

Research output: Chapter in Book/Report/Conference proceedingChapter


Auditory processing requires a balanced participation of synaptic inhibition and excitation. This balance is achieved during development, in part, through the refinement of inhibitory connections and the regulation of inhibitory functional properties. Here, we make the case that spontaneous and experience-driven activity contributes to these maturational events in the auditory brainstem and cortex. Using brain slice preparations, we selectively assessed the physiology and plasticity of central inhibitory transmission. Together, the results demonstrate that inhibitory synapse function is regulated at every central location examined. The sites of regulation involve presynaptic factors such as transmitter synthesis and release properties, as well as postsynaptic factors such as receptor subunit kinetics, KCC2 function, and long-term depression. We propose that reduced inhibitory strength following disuse is due to delayed development, and this may contribute the enhanced excitability.

Original languageEnglish (US)
Title of host publicationDevelopmental Plasticity of Inhibitory Circuitry
PublisherSpringer US
Number of pages27
ISBN (Electronic)9781441912435
ISBN (Print)9781441912428
StatePublished - 2010

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience


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