TY - JOUR
T1 - Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins
AU - Dejean, Laurent M.
AU - Martinez-Caballero, Sonia
AU - Manon, Stephen
AU - Kinnally, Kathleen W.
N1 - Funding Information:
This research was supported by NIH grant GM57249 and NSF grants MCB-0235834 and INT003797 to KWK. Research in the laboratory of S.M. was supported by the Centre National de la Recherche Scientifique, the Association pour la Recherche contre le Cancer, the Conseil Régional d'Aquitaine and the Université Victor Segalen-Bordeaux 2. We thank Cynthia Hughes for her excellent technical assistance and Francois Ichas for his help with the GFP-Bax experiments.
PY - 2006/2
Y1 - 2006/2
N2 - Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed.
AB - Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed.
KW - Apoptosis
KW - Bax
KW - Bcl-2
KW - MAC
KW - Mitochondrial apoptosis-induced channel
KW - Patch clamp
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U2 - 10.1016/j.bbadis.2005.07.002
DO - 10.1016/j.bbadis.2005.07.002
M3 - Review article
C2 - 16055309
AN - SCOPUS:29344454248
SN - 0925-4439
VL - 1762
SP - 191
EP - 201
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 2
ER -