Regulation of the X chromosomes in Caenorhabditis elegans

Susan Strome, William G. Kelly, Sevinc Ercan, Jason D. Lieb

Research output: Contribution to journalArticlepeer-review


Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Biology
Issue number3
StatePublished - Mar 2014

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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