Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.
|Original language||English (US)|
|Journal||Cold Spring Harbor Perspectives in Biology|
|State||Published - Mar 2014|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)