Regulation of the X chromosomes in Caenorhabditis elegans

Susan Strome; William G. Kelly; Sevinc Ercan; Jason D. Lieb

doi:10.1101/cshperspect.a018366

Regulation of the X chromosomes in Caenorhabditis elegans

Susan Strome, William G. Kelly, Sevinc Ercan, Jason D. Lieb

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

Original language	English (US)
Journal	Cold Spring Harbor Perspectives in Biology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1101/cshperspect.a018366
State	Published - Mar 2014

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Regulation of the X chromosomes in Caenorhabditis elegans

Abstract

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