TY - JOUR
T1 - Relation of dietary glycemic index and glycemic load to coronary artery calcium in asymptomatic Korean adults
AU - Choi, Yuni
AU - Chang, Yoosoo
AU - Ryu, Seungho
AU - Cho, Juhee
AU - Kim, Mi Kyung
AU - Ahn, Younjhin
AU - Lee, Jung Eun
AU - Sung, Eunju
AU - Kim, Boyoung
AU - Ahn, Jiin
AU - Kim, Chan Won
AU - Rampal, Sanjay
AU - Zhao, Di
AU - Zhang, Yiyi
AU - Pastor-Barriuso, Roberto
AU - Lima, Joao A.C.
AU - Chung, Eun Chul
AU - Shin, Hocheol
AU - Guallar, Eliseo
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - The relation between glycemic index, glycemic load, and subclinical coronary atherosclerosis is unknown. The aim of the study was to evaluate the associations between energy-adjusted glycemic index, glycemic load, and coronary artery calcium (CAC). This study was cross-sectional analysis of 28,429 asymptomatic Korean men and women (mean age 41.4 years) without a history of diabetes or cardiovascular disease. All participants underwent a health screening examination between March 2011 and April 2013, and dietary intake over the preceding year was estimated using a validated food frequency questionnaire. Cardiac computed tomography was used for CAC scoring. The prevalence of detectable CAC (CAC score >0) was 12.4%. In multivariable-adjusted models, the CAC score ratios (95% confidence intervals) comparing the highest to the lowest quintile of glycemic index and glycemic load were 1.74 (1.08 to 2.81; p trend = 0.03) and 3.04 (1.43 to 6.46; p trend = 0.005), respectively. These associations did not differ by clinical subgroups, including the participants at low cardiovascular risk. In conclusion, these findings suggest that high dietary glycemic index and glycemic load were associated with a greater prevalence and degree of CAC, with glycemic load having a stronger association.
AB - The relation between glycemic index, glycemic load, and subclinical coronary atherosclerosis is unknown. The aim of the study was to evaluate the associations between energy-adjusted glycemic index, glycemic load, and coronary artery calcium (CAC). This study was cross-sectional analysis of 28,429 asymptomatic Korean men and women (mean age 41.4 years) without a history of diabetes or cardiovascular disease. All participants underwent a health screening examination between March 2011 and April 2013, and dietary intake over the preceding year was estimated using a validated food frequency questionnaire. Cardiac computed tomography was used for CAC scoring. The prevalence of detectable CAC (CAC score >0) was 12.4%. In multivariable-adjusted models, the CAC score ratios (95% confidence intervals) comparing the highest to the lowest quintile of glycemic index and glycemic load were 1.74 (1.08 to 2.81; p trend = 0.03) and 3.04 (1.43 to 6.46; p trend = 0.005), respectively. These associations did not differ by clinical subgroups, including the participants at low cardiovascular risk. In conclusion, these findings suggest that high dietary glycemic index and glycemic load were associated with a greater prevalence and degree of CAC, with glycemic load having a stronger association.
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U2 - 10.1016/j.amjcard.2015.05.005
DO - 10.1016/j.amjcard.2015.05.005
M3 - Article
C2 - 26073677
AN - SCOPUS:84938197324
SN - 0002-9149
VL - 116
SP - 520
EP - 526
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 4
ER -