Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
- Human immunodeficiency virus
- Mathematical model
- Virological synapse
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Agricultural and Biological Sciences(all)