Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe, Ian M. Jones, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation. This journal is

Original languageEnglish (US)
Pages (from-to)9384-9388
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number46
DOIs
StatePublished - Dec 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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