Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe; Ian M. Jones; Sam Thompson; Andrew D. Hamilton

doi:10.1039/c4ob01991a

Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe, Ian M. Jones, Sam Thompson, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.

Original language	English (US)
Pages (from-to)	9384-9388
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	46
DOIs	https://doi.org/10.1039/c4ob01991a
State	Published - Dec 14 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c4ob01991a

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abstract = "Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.",

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AU - Hamilton, Andrew D.

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AB - Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.

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Remote conformational control of a molecular switch via methylation and deprotonation

Abstract

ASJC Scopus subject areas

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