TY - JOUR
T1 - Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development
AU - Jordan, Robert
AU - Ford-Scheimer, Stephanie L.
AU - Alarcon, Rodolfo M.
AU - Atala, Anthony
AU - Borenstein, Jeffrey T.
AU - Brimacombe, Kyle R.
AU - Cherry, Sara
AU - Clevers, Hans
AU - Davis, Mindy I.
AU - Funnell, Simon G.P.
AU - Gehrke, Lee
AU - Griffith, Linda G.
AU - Grossman, Abigail C.
AU - Hartung, Thomas
AU - Ingber, Donald E.
AU - Kleinstreuer, Nicole C.
AU - Kuo, Calvin J.
AU - Lee, Emily M.
AU - Mummery, Christine L.
AU - Pickett, Thames E.
AU - Ramani, Sasirekha
AU - Rosado-Olivieri, Edwin A.
AU - Struble, Evi B.
AU - Wan, Zhengpeng
AU - Williams, Mark S.
AU - Hall, Matthew D.
AU - Ferrer, Marc
AU - Markossian, Sarine
N1 - Publisher Copyright:
© 2023 Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/10/1
Y1 - 2023/10/1
N2 - The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral drug development, practical advice, best practices, and case studies about the application of available 3D tissue models to infectious disease modeling. This report includes a summary of each workshop session as well as a discussion of perspectives and challenges related to the use of 3D tissues in antiviral drug discovery.
AB - The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral drug development, practical advice, best practices, and case studies about the application of available 3D tissue models to infectious disease modeling. This report includes a summary of each workshop session as well as a discussion of perspectives and challenges related to the use of 3D tissues in antiviral drug discovery.
KW - 3D tissue models
KW - SARS-CoV-2
KW - antiviral drug discovery
KW - body-on-a-chip
KW - human pluripotent stem cells (hPSCs)
KW - induced pluripotent stem cells (iPSCs)
KW - microphysiological systems (MPS)
KW - organ-on-a-chip
KW - organoid
KW - tissue-derived stem cells
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U2 - 10.1093/infdis/jiad334
DO - 10.1093/infdis/jiad334
M3 - Article
C2 - 37669225
AN - SCOPUS:85173572190
SN - 0022-1899
VL - 228
SP - S337-S354
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -