Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Robert A. Avery, Avital Cnaan, Joel S. Schuman, Chieh Li Chen, Natalie C. Glaug, Roger J. Packer, Graham E. Quinn, Hiroshi Ishikawa

    Research output: Contribution to journalArticlepeer-review


    PURPOSE: To determine the intra- And intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) measures using handheld optical coherence tomography (OCT) in sedated children. DESIGN: Prospective cross-sectional and longitudinal study. METHODS: Children undergoing sedation for a clinically indicated magnetic resonance imaging for an optic pathway glioma and/or neurofibromatosis type 1 (NF1) had multiple 6 3 6 mm volumes (isotropic 300 3 300 or nonisotropic 1000 3 100 samplings) acquired over the optic nerve. Children with 2 handheld OCT sessions within 6 months were included in the intervisit cohort. The intra- And intervisit coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for the average and anatomic quadrant circumpapillary RNFL thickness. RESULTS: Fifty-nine subjects (mean age 5.1 years, range 0.8-13.0 years) comprised the intravisit cohort and 29 subjects (mean age 5.7 years, range 1.8-12.7 years) contributed to the intervisit cohort. Forty-nine subjects had an optic pathway glioma and 10 subjects hadNF1 without an optic pathway glioma. TheCVwas comparable regardless of imaging with an isotropic and nonisotropic volume in both the intra- And intervisit cohorts. The average circumpapillary RNFL demonstrated the lowest CV and highest ICC compared to the quadrants. For the intervisit cohort, the average ICC was typically higher while the CV was typically lower, but not statistically different compared to the other quadrants. DISCUSSION: Circumpapillary RNFL measures acquired with handheld OCT during sedation demonstrate good intra- And intervisit reproducibility. Handheld OCT has the potential to monitor progressive optic neuropathies in young children who have difficulty cooperating with traditional OCT devices.

    Original languageEnglish (US)
    Pages (from-to)780-787.e1
    JournalAmerican Journal of Ophthalmology
    Issue number4
    StatePublished - 2014

    ASJC Scopus subject areas

    • Ophthalmology

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