Resistant hypertension and sleep apnea: Pathophysiologic insights and strategic management

Stephen K. Williams; Joseph Ravenell; Girardin Jean-Louis; Ferdinand Zizi; James A. Underberg; Samy I. McFarlane; Gbenga Ogedegbe

doi:10.1007/s11892-010-0161-z

Resistant hypertension and sleep apnea: Pathophysiologic insights and strategic management

Stephen K. Williams, Joseph Ravenell, Girardin Jean-Louis, Ferdinand Zizi, James A. Underberg, Samy I. McFarlane, Gbenga Ogedegbe

Research output: Contribution to journal › Article › peer-review

Abstract

Resistant hypertension is common among adults with hypertension affecting up to 30% of patients. The treatment of resistant hypertension is important because suboptimal blood pressure control is the leading preventable cause of death worldwide. A frequent comorbid condition in patients with resistant hypertension is obstructive sleep apnea. The pathophysiology of sleep apnea-associated hypertension is characterized by sustained adrenergic activation and volume retention often posing treatment challenges in patients with resistant hypertension. This review will address some of the epidemiologic data associating apnea with the pathogenesis of resistant hypertension. Diagnosis and management of apnea and its associated hypertension will also be considered.

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Current Diabetes Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s11892-010-0161-z
State	Published - Feb 2011

Keywords

Continuous positive airway pressure
Diuretics
Drug-resistant hypertension
Obesity
Sleep apnea
Sleep-disordered breathing

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/s11892-010-0161-z

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abstract = "Resistant hypertension is common among adults with hypertension affecting up to 30% of patients. The treatment of resistant hypertension is important because suboptimal blood pressure control is the leading preventable cause of death worldwide. A frequent comorbid condition in patients with resistant hypertension is obstructive sleep apnea. The pathophysiology of sleep apnea-associated hypertension is characterized by sustained adrenergic activation and volume retention often posing treatment challenges in patients with resistant hypertension. This review will address some of the epidemiologic data associating apnea with the pathogenesis of resistant hypertension. Diagnosis and management of apnea and its associated hypertension will also be considered.",

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AU - Jean-Louis, Girardin

AU - Zizi, Ferdinand

AU - Underberg, James A.

AU - McFarlane, Samy I.

AU - Ogedegbe, Gbenga

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KW - Continuous positive airway pressure

KW - Diuretics

KW - Drug-resistant hypertension

KW - Obesity

KW - Sleep apnea

KW - Sleep-disordered breathing

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Resistant hypertension and sleep apnea: Pathophysiologic insights and strategic management

Abstract

Keywords

ASJC Scopus subject areas

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