Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion

D. Keng; S. R. McAnanama; I. Teraoka; S. Arnold

doi:10.1063/1.2778351

Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion

D. Keng, S. R. McAnanama, I. Teraoka, S. Arnold

Research output: Contribution to journal › Article › peer-review

Abstract

Nanoparticles suspended in the vicinity of a whispering gallery mode (WGM) biosensor are detected from fluctuations in the driving light-guide transmission. These fluctuations are described by Brownian particles perturbing the resonance wavelength in reaction to being polarized by the WGM's evanescent field. Comparison between the autocorrelation of the measured fluctuations and theory provides a first order approximation for the nanoparticle size and lays the basis for future studies of interfacial dynamics. With this advance, the WGM biosensor goes beyond low-frequency measurements of adsorption and desorption and into a world which has been dominated by fluorescence correlation spectroscopy, but without labels.

Original language	English (US)
Article number	103902
Journal	Applied Physics Letters
Volume	91
Issue number	10
DOIs	https://doi.org/10.1063/1.2778351
State	Published - 2007

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2778351

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title = "Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion",

abstract = "Nanoparticles suspended in the vicinity of a whispering gallery mode (WGM) biosensor are detected from fluctuations in the driving light-guide transmission. These fluctuations are described by Brownian particles perturbing the resonance wavelength in reaction to being polarized by the WGM's evanescent field. Comparison between the autocorrelation of the measured fluctuations and theory provides a first order approximation for the nanoparticle size and lays the basis for future studies of interfacial dynamics. With this advance, the WGM biosensor goes beyond low-frequency measurements of adsorption and desorption and into a world which has been dominated by fluorescence correlation spectroscopy, but without labels.",

author = "D. Keng and McAnanama, {S. R.} and I. Teraoka and S. Arnold",

note = "Funding Information: This research was supported by NSF through Division of Bioengineering and Environmental Systems Grant No. 0522668. The authors thank Steve Holler of Novawave Technologies Inc. and Ralph v. Baltz of Universit{\"a}t Karlsruhe for valuable discussions. ",

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AU - Keng, D.

AU - McAnanama, S. R.

AU - Teraoka, I.

AU - Arnold, S.

N1 - Funding Information: This research was supported by NSF through Division of Bioengineering and Environmental Systems Grant No. 0522668. The authors thank Steve Holler of Novawave Technologies Inc. and Ralph v. Baltz of Universität Karlsruhe for valuable discussions.

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AB - Nanoparticles suspended in the vicinity of a whispering gallery mode (WGM) biosensor are detected from fluctuations in the driving light-guide transmission. These fluctuations are described by Brownian particles perturbing the resonance wavelength in reaction to being polarized by the WGM's evanescent field. Comparison between the autocorrelation of the measured fluctuations and theory provides a first order approximation for the nanoparticle size and lays the basis for future studies of interfacial dynamics. With this advance, the WGM biosensor goes beyond low-frequency measurements of adsorption and desorption and into a world which has been dominated by fluorescence correlation spectroscopy, but without labels.

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Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion

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