Response to Dr Stephen Cooper's 'On the use of metaphor to understand, explain, or rationalize redundant genes in yeast'

Xuewen Pan, Daniel Yuan, Ping Ye, Joel Bader, Jef D. Boeke

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Earlier use of a metaphor in explaining genetic redundancy in a news article has triggered a commentary and a competing metaphor by Dr Stephen Cooper, who went on to conclude that genetic redundancies are relatively unimportant for microorganisms. We argue here that the new metaphor is flawed and that genetic redundancies are integral to buffering all organisms against environmental and genetic damage.

    Original languageEnglish (US)
    Pages (from-to)349-350
    Number of pages2
    JournalFEMS Yeast Research
    Volume8
    Issue number3
    DOIs
    StatePublished - May 2008

    Keywords

    • DNA repair
    • DNA replication
    • Genetic interactions
    • Saccharomyces cerevisiae
    • Synthetic lethality

    ASJC Scopus subject areas

    • Microbiology
    • Applied Microbiology and Biotechnology

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