TY - JOUR
T1 - Response Variation following Trauma
T2 - A Translational Neuroscience Approach to Understanding PTSD
AU - Yehuda, Rachel
AU - LeDoux, Joseph
N1 - Funding Information:
This work was supported by NIH (R01 MH064675-02, R01 MH64104-01, R56MH077321), Department of Defense Grant W18XWH-06-2-0032, and VA Merit funding (R.Y.) and by NIH (P50MH58911, R37 MH38774, R01 MH46516, K05 MH067048) (J.L.). The authors wish to thank Dr. Julia Golier for reading several drafts of this manuscript. We also thank Janelle Wohltmann for her assistance in the literature review and manuscript preparation.
PY - 2007/10/4
Y1 - 2007/10/4
N2 - Exposure to traumatic stress is a requirement for the development of posttraumatic stress disorder (PTSD). However, because the majority of trauma-exposed persons do not develop PTSD, examination of the typical effects of a stressor will not identify the critical components of PTSD risk or pathogenesis. Rather, PTSD represents a specific phenotype associated with a failure to recover from the normal effects of trauma. Thus, research must focus on identifying pre- and posttraumatic risk factors that explain the development of the disorder and the failure to reinstate physiological homeostasis. In this review, we summarize what is known about the clinical and biological characteristics of PTSD and articulate some of the gaps in knowledge that can be addressed by basic neuroscience research. We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD.
AB - Exposure to traumatic stress is a requirement for the development of posttraumatic stress disorder (PTSD). However, because the majority of trauma-exposed persons do not develop PTSD, examination of the typical effects of a stressor will not identify the critical components of PTSD risk or pathogenesis. Rather, PTSD represents a specific phenotype associated with a failure to recover from the normal effects of trauma. Thus, research must focus on identifying pre- and posttraumatic risk factors that explain the development of the disorder and the failure to reinstate physiological homeostasis. In this review, we summarize what is known about the clinical and biological characteristics of PTSD and articulate some of the gaps in knowledge that can be addressed by basic neuroscience research. We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD.
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U2 - 10.1016/j.neuron.2007.09.006
DO - 10.1016/j.neuron.2007.09.006
M3 - Review article
C2 - 17920012
AN - SCOPUS:34748854338
SN - 0896-6273
VL - 56
SP - 19
EP - 32
JO - Neuron
JF - Neuron
IS - 1
ER -