TY - JOUR
T1 - Resuscitation, survival and morbidity of extremely preterm infants in California 2011–2019
AU - Higgins, Brennan V.
AU - Baer, Rebecca J.
AU - Steurer, Martina A.
AU - Karvonen, Kayla L.
AU - Oltman, Scott P.
AU - Jelliffe-Pawlowski, Laura L.
AU - Rogers, Elizabeth E.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2024/2
Y1 - 2024/2
N2 - Objective: To describe changes over time in resuscitation, survival, and morbidity of extremely preterm infants in California. Study design: This population-based, retrospective cohort study includes infants born ≤28 weeks. Linked birth certificates and hospital discharge records were used to evaluate active resuscitation, survival, and morbidity across two epochs (2011–2014, 2015–2019). Results: Of liveborn infants, 0.6% were born ≤28 weeks. Active resuscitation increased from 16.9% of 22-week infants to 98.1% of 25-week infants and increased over time in 22-, 23-, and 25-week infants (p-value ≤ 0.01). Among resuscitated infants, survival to discharge increased from 33.2% at 22 weeks to 96.1% at 28 weeks. Survival without major morbidity improved over time for 28-week infants (p-value < 0.01). Conclusion: Among infants ≤28 weeks, resuscitation and survival increased with gestational age and morbidity decreased. Over time, active resuscitation of periviable infants and morbidity-free survival of 28-week infants increased. These trends may inform counseling around extremely preterm birth.
AB - Objective: To describe changes over time in resuscitation, survival, and morbidity of extremely preterm infants in California. Study design: This population-based, retrospective cohort study includes infants born ≤28 weeks. Linked birth certificates and hospital discharge records were used to evaluate active resuscitation, survival, and morbidity across two epochs (2011–2014, 2015–2019). Results: Of liveborn infants, 0.6% were born ≤28 weeks. Active resuscitation increased from 16.9% of 22-week infants to 98.1% of 25-week infants and increased over time in 22-, 23-, and 25-week infants (p-value ≤ 0.01). Among resuscitated infants, survival to discharge increased from 33.2% at 22 weeks to 96.1% at 28 weeks. Survival without major morbidity improved over time for 28-week infants (p-value < 0.01). Conclusion: Among infants ≤28 weeks, resuscitation and survival increased with gestational age and morbidity decreased. Over time, active resuscitation of periviable infants and morbidity-free survival of 28-week infants increased. These trends may inform counseling around extremely preterm birth.
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U2 - 10.1038/s41372-023-01774-6
DO - 10.1038/s41372-023-01774-6
M3 - Article
C2 - 37689808
AN - SCOPUS:85184296808
SN - 0743-8346
VL - 44
SP - 209
EP - 216
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 2
ER -