Retinal blood flow reduction in normal-Tension glaucoma with single-hemifield damage by Doppler optical coherence tomography

Takafumi Yoshioka, Youngseok Song, Motofumi Kawai, Tomofumi Tani, Kengo Takahashi, Satoshi Ishiko, Fabio Lavinsky, Gadi Wollstein, Hiroshi Ishikawa, Joel S. Schuman, Akitoshi Yoshida

    Research output: Contribution to journalArticle

    Abstract

    Aims: To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-Tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT. Methods: The Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fibre layer thickness (RNFLT) was measured by spectral-domain OCT. Results: Forty-Three consecutive eyes of 43 patients with NTG with VF defect confined to a single hemifield and 24 eyes of 24 age-matched healthy subjects were studied. TA and TV RBF and RNFLT were reduced in the damaged hemisphere compared with the normal hemisphere (mean (SD), 3.61 (1.68) vs 5.86 (2.59) μL/min, p<0.001; 5.61 (2.51) vs 6.94 (2.83) μL/min, p=0.010; 69.0 (19.7) vs 99.7 (22.8) μm, p<0.001). Those values in the normal hemisphere of NTG eyes also decreased compared with the healthy hemisphere of the healthy eyes (8.40 (3.36) μL/min, p<0.001; 9.28 (4.47) μL/min, p<0.002; 122.8 (20.2) μm, p<0.001). Multivariate model showed that normal and damaged hemispheres and RNFLT were associated with RBF reduction. In addition, the RBF in the normal hemisphere was lower than that in the healthy hemisphere even after adjusting for RNFLT. Conclusion: In NTG eyes with single-hemifield damage, the RBF was significantly reduced in the damaged hemisphere compared with the normal one. The RBF decreased in the normal and damaged hemispheres of NTG eyes compared with the healthy hemisphere independent from RNFLT.

    Original languageEnglish (US)
    Article number2019315616
    JournalBritish Journal of Ophthalmology
    DOIs
    StateAccepted/In press - 2020

    Keywords

    • field of vision
    • glaucoma
    • imaging
    • retina

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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