Retrotransposons

Jef D. Boeke

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Retrotransposons constitute an extensively distributed family of eukaryotic transposable elements. The retrotransposons share a number of structural features which reflect the mechanism by which new copies of the transposon are generated; this process is similar to that of retroviral reverse transcription and integration. In this review, several aspects of retrotransposon biology in light of recent investigations will be considered. Specifically, this review will summarize recent findings on the mechanism and regulation of retrotransposition, the structure of the elements, roles of the encoded gene product(s) in transposition, interactions between retrotransposons and adjacent host genes, and interactions between retrotransposons and host gene products (i.e., the insertion suppressors). Several other recent reviews of these topics are also available. 1 - 12 This review will concern itself primarily with 61yeast and insect elements, although where possible, results from vertebrate systems are also incorporated. Not discussed is another major class of eukaryotic transposons, typified by the P and Ac elements, which are characterized by short inverted terminal repeats.

    Original languageEnglish (US)
    Title of host publicationRNA Genetics
    Subtitle of host publicationVolume II: Retroviruses, Viroids, and RNA Recombination
    PublisherCRC Press
    Pages59-103
    Number of pages45
    ISBN (Electronic)9781351084888
    ISBN (Print)9781315897332
    DOIs
    StatePublished - Jan 1 2018

    ASJC Scopus subject areas

    • Immunology and Microbiology(all)

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  • Cite this

    Boeke, J. D. (2018). Retrotransposons. In RNA Genetics: Volume II: Retroviruses, Viroids, and RNA Recombination (pp. 59-103). CRC Press. https://doi.org/10.1201/9781351076432