Revascularization of Immature Necrotic Teeth

Nikita B. Ruparel, Vanessa Chrepa, Jennifer L. Gibbs

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The objective of this review is to provide an overview of the past and present advancements in regenerative endodontics. Recent Findings: Available literature clearly demonstrates high-clinical success of regenerative endodontic procedures (REP). Several recommendations made by the American Association of Endodontists (AAE) with regard to REP protocols are based on recent work demonstrating these as stem cell-based therapies. This review summarizes the role of stem cells and therefore the rationale for the currently recommended guidelines. Summary: Clinical success of REP lies between 80 and 100% with root development observed in a significant number of treated cases. These procedures provide a unique advantage of continued root growth despite premature pulp necrosis in immature teeth. Research in the field of stem cell biology has greatly increased our understanding of tissue engineering in endodontics. Overall, REPs appear to be a viable treatment option for immature teeth with pulp necrosis.

Original languageEnglish (US)
Pages (from-to)319-329
Number of pages11
JournalCurrent Oral Health Reports
Issue number4
StatePublished - Dec 2017


  • Immature necrotic teeth
  • Regenerative endodontics
  • Revascularization
  • Root canal
  • Root development
  • Stem cells

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Oral Surgery
  • Surgery


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