Reversible self-assembly and directed assembly of DNA-linked micrometer-sized colloids

Marie Pierre Valignat; Olivier Theodoly; John C. Crocker; William B. Russel; Paul M. Chaikin

doi:10.1073/pnas.0500507102

Reversible self-assembly and directed assembly of DNA-linked micrometer-sized colloids

Marie Pierre Valignat, Olivier Theodoly, John C. Crocker, William B. Russel, Paul M. Chaikin

Research output: Contribution to journal › Article › peer-review

Abstract

We present a technique for the directed assembly and self-assembly of micrometer-scale structures based on the control of specific DNA linkages between colloidal particles. The use of DNA links combined with polymer brushes provides an effective way to regulate the range and magnitude of addressable forces between pairs (and further combinations) of different particles. We demonstrate that the autoassembly of alternate microbeads as well as their directed assembly, by using laser tweezers, is reversible. The key to reversibility is preventing the particles from falling into their van der Waals well at close distances. This goal is achieved by the use of adsorbed polymers that limit the number of DNA bridges to one to three between adjacent particles.

Original language	English (US)
Pages (from-to)	4225-4229
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	12
DOIs	https://doi.org/10.1073/pnas.0500507102
State	Published - Mar 22 2005

Keywords

DNA links
Reversible aggregation

ASJC Scopus subject areas

General

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10.1073/pnas.0500507102

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abstract = "We present a technique for the directed assembly and self-assembly of micrometer-scale structures based on the control of specific DNA linkages between colloidal particles. The use of DNA links combined with polymer brushes provides an effective way to regulate the range and magnitude of addressable forces between pairs (and further combinations) of different particles. We demonstrate that the autoassembly of alternate microbeads as well as their directed assembly, by using laser tweezers, is reversible. The key to reversibility is preventing the particles from falling into their van der Waals well at close distances. This goal is achieved by the use of adsorbed polymers that limit the number of DNA bridges to one to three between adjacent particles.",

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AU - Theodoly, Olivier

AU - Crocker, John C.

AU - Russel, William B.

AU - Chaikin, Paul M.

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AB - We present a technique for the directed assembly and self-assembly of micrometer-scale structures based on the control of specific DNA linkages between colloidal particles. The use of DNA links combined with polymer brushes provides an effective way to regulate the range and magnitude of addressable forces between pairs (and further combinations) of different particles. We demonstrate that the autoassembly of alternate microbeads as well as their directed assembly, by using laser tweezers, is reversible. The key to reversibility is preventing the particles from falling into their van der Waals well at close distances. This goal is achieved by the use of adsorbed polymers that limit the number of DNA bridges to one to three between adjacent particles.

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KW - Reversible aggregation

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Reversible self-assembly and directed assembly of DNA-linked micrometer-sized colloids

Abstract

Keywords

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