Reversible self-assembly and directed assembly of DNA-linked micrometer-sized colloids

Marie Pierre Valignat, Olivier Theodoly, John C. Crocker, William B. Russel, Paul M. Chaikin

    Research output: Contribution to journalArticlepeer-review


    We present a technique for the directed assembly and self-assembly of micrometer-scale structures based on the control of specific DNA linkages between colloidal particles. The use of DNA links combined with polymer brushes provides an effective way to regulate the range and magnitude of addressable forces between pairs (and further combinations) of different particles. We demonstrate that the autoassembly of alternate microbeads as well as their directed assembly, by using laser tweezers, is reversible. The key to reversibility is preventing the particles from falling into their van der Waals well at close distances. This goal is achieved by the use of adsorbed polymers that limit the number of DNA bridges to one to three between adjacent particles.

    Original languageEnglish (US)
    Pages (from-to)4225-4229
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Issue number12
    StatePublished - Mar 22 2005


    • DNA links
    • Reversible aggregation

    ASJC Scopus subject areas

    • General


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