Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide A

Brent K. Rubio; Sarah J. Robinson; Claudia E. Avalos; Frederick A. Valeriote; Nicole J. De Voogd; Phillip Crews

doi:10.1021/np800230d

Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide A

Brent K. Rubio, Sarah J. Robinson, Claudia E. Avalos, Frederick A. Valeriote, Nicole J. De Voogd, Phillip Crews

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S.

Original language	English (US)
Pages (from-to)	1475-1478
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	8
DOIs	https://doi.org/10.1021/np800230d
State	Published - Aug 2008

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S.",

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AU - Valeriote, Frederick A.

AU - De Voogd, Nicole J.

AU - Crews, Phillip

PY - 2008/8

Y1 - 2008/8

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AB - The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S.

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Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide A

Abstract

ASJC Scopus subject areas

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