Abstract
Strong gap-junctional coupling can synchronize the electrical oscillations of cells, but we show, in a theoretical model, that weak coupling can phase lock two cells 180° out-of-phase. Antiphase oscillations can exist in parameter regimes where in-phase oscillations break down. Some consequences are (i) coupling two excitable cells leads to pacemaking, (ii) coupling two pacemaker cells leads to bursting, and (iii) coupling two bursters increases burst period. The latter shows that details of the fast spikes can affect macroscopic properties of the slow bursts. These effects hold in other models for bursting and may play a role in the collective behavior of cellular ensembles.
Original language | English (US) |
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Pages (from-to) | 2471-2474 |
Number of pages | 4 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 89 |
Issue number | 6 |
State | Published - 1992 |
Keywords
- Bursting oscillations
- Coupled oscillators
- Gap junctions
ASJC Scopus subject areas
- General