Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein

R. J. Baer; C. D. Chambers; K. K. Ryckman; S. P. Oltman; M. E. Norton; L. L. Jelliffe-Pawlowski

doi:10.1038/jp.2016.224

Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein

R. J. Baer, C. D. Chambers, K. K. Ryckman, S. P. Oltman, M. E. Norton, L. L. Jelliffe-Pawlowski

Nursing

Research output: Contribution to journal › Article › peer-review

Abstract

Objective:Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated-fetoprotein (AFP).Study Design:The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.Results:We identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ≥95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ≥95th percentile were 11 to 35 times as likely to deliver <32 weeks.Conclusion:The combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.

Original language	English (US)
Pages (from-to)	220-225
Number of pages	6
Journal	Journal of Perinatology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1038/jp.2016.224
State	Published - Mar 1 2017

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/jp.2016.224

Cite this

@article{88172de2ee214b778f200a5dffc046f1,

title = "Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein",

abstract = "Objective:Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated-fetoprotein (AFP).Study Design:The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.Results:We identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ≥95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ≥95th percentile were 11 to 35 times as likely to deliver <32 weeks.Conclusion:The combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.",

author = "Baer, {R. J.} and Chambers, {C. D.} and Ryckman, {K. K.} and Oltman, {S. P.} and Norton, {M. E.} and Jelliffe-Pawlowski, {L. L.}",

year = "2017",

month = mar,

day = "1",

doi = "10.1038/jp.2016.224",

language = "English (US)",

volume = "37",

pages = "220--225",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Springer Nature",

number = "3",

}

TY - JOUR

T1 - Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein

AU - Baer, R. J.

AU - Chambers, C. D.

AU - Ryckman, K. K.

AU - Oltman, S. P.

AU - Norton, M. E.

AU - Jelliffe-Pawlowski, L. L.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective:Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated-fetoprotein (AFP).Study Design:The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.Results:We identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ≥95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ≥95th percentile were 11 to 35 times as likely to deliver <32 weeks.Conclusion:The combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.

AB - Objective:Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated-fetoprotein (AFP).Study Design:The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.Results:We identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ≥95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ≥95th percentile were 11 to 35 times as likely to deliver <32 weeks.Conclusion:The combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.

UR - http://www.scopus.com/inward/record.url?scp=85001790764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85001790764&partnerID=8YFLogxK

U2 - 10.1038/jp.2016.224

DO - 10.1038/jp.2016.224

M3 - Article

C2 - 27929528

AN - SCOPUS:85001790764

SN - 0743-8346

VL - 37

SP - 220

EP - 225

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 3

ER -

Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this