RNA used to control a DNA rotary nanomachine

Hong Zhong, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


The PX-JX2 device is a robust sequence-dependent DNA nanomachine. It is controlled by the addition of DNA strands to the solution. The ability to control such devices with RNA will enable the machine to respond to signals generated by transcriptional logic circuits in vitro or, possibly, in vivo. The PX-JX2 device does not respond properly to RNA strands, so we have adapted the signaling method by using a cover-strand strategy, This approach entails using DNA control strands that contain sequence regions to set the device to either state. An RNA strand is used to mask one of these two regions, enabling the machine to assume the state corresponding to the unmasked region.

Original languageEnglish (US)
Pages (from-to)2899-2903
Number of pages5
JournalNano Letters
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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