Abstract
In this study we analyze the possibility that endothelial cells grown on adhesion peptide-grafted substrates may exhibit altered physiological responses to microinjuries. Peptide-grafted substrates show considerable potential for use as materials that support and promote endothelialization. The REDV substrate can support endothelial cell-specific adhesion and proliferation, and REDV-, RGD-, and YIGSR-supported endothelial monolayers all appeared to maintain their nonthrombogenic properties. By contrast, PDSGR-supported monolayers were very thrombogenic. These results illustrate the important influences that adhesion substrates exert upon endothelial cell function.
| Original language | English (US) |
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| Pages | 239 |
| Number of pages | 1 |
| State | Published - 1991 |
| Event | 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA Duration: May 1 1991 → May 5 1991 |
Other
| Other | 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium |
|---|---|
| City | Scottsdale, AZ, USA |
| Period | 5/1/91 → 5/5/91 |
ASJC Scopus subject areas
- General Materials Science