Role of neuropeptide Y projection on the development of serotonergic innervation in the suprachiasmatic nucleus of the rat, shown by triple intraocular grafts

Shuichi Ueda, Yasuhiro Matsumoto, Akira Nisimura, Efrain C. Azmitia, Mitsuhiro Kawata

Research output: Contribution to journalArticlepeer-review

Abstract

In our previous paper, the intraocular double grafts of fetal mesencephalic raphe and suprachiasmatic nucleus (SCN) demonstrated that the serotonergic fibers from raphe tissue did not show a dense innervation of SCN [28]. To examine the influence of NPY innervation from lateral geniculate nucleus (LGN) on the development of serotonergic fibers in the SCN, fetal mesencephalic raphe, SCN and LGN tissues were transplanted together into the eye chamber of adult rat. 6 weeks after transplantation, triple grafts were immunohistochemically examined. The SCN cell cluster was recognized by vasoactive intestinal polypeptide (VIP)- and arginine vasopressin (AVP)-immunoreactive neurons and fibers. The SCN cell cluster also contained a large number of serotonin-immunoreactive fibers from raphe tissue and a moderate number of neuropeptide Y (NPY)-immunoreactive fibers from LGN tissue. The present results provide information on possible NPY-serotonin interactions in the developing SCN.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalBrain Research
Volume673
Issue number2
DOIs
StatePublished - Mar 6 1995

Keywords

  • Intraocular transplant
  • Neuropeptide Y
  • Serotonin
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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