Rules of tumor cell development and their application to biomarkers for ovarian cancer

Monica R. McLemore, Christine Miaskowski, Bradley E. Aouizerat, Lee May Chen, Marylin Dodd

Research output: Contribution to journalArticle

Abstract

Purpose/Objectives: To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed in ovarian cancer. Data Sources: Data-based publications, topical reviews, and book chapters. Data Synthesis: Articles specific to ovarian cancer were reviewed to examine whether the six rules from the Hanahan and Weinberg conceptual framework were applicable to biomarkers of ovarian cancer. This approach allows for the application of a general framework for the development of solid tumors to the development of ovarian cancer. Conclusions: The six rules for tumor cell development outlined in the Hanahan and Weinberg conceptual framework are applicable to biomarkers expressed or observed in patients with ovarian cancer. Implications for Nursing: Oncology nurses can enhance their clinical teaching by integrating this information into their practice. Nurses who conduct research on ovarian cancer can use this framework to guide the selection of biomarker(s) for these studies. Finally, nurse educators can use this framework when teaching students key concepts in the care of patients with cancer.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalOncology nursing forum
Volume35
Issue number3
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Oncology(nursing)

Fingerprint Dive into the research topics of 'Rules of tumor cell development and their application to biomarkers for ovarian cancer'. Together they form a unique fingerprint.

  • Cite this