S100β and serotonin: A possible astrocytic-neuronal link to neuropathology of Alzheimer's disease

E. C. Azmitia; W. S T Griffin; D. R. Marshak; L. J. Van Eldik; P. M. Whitaker-Azmitia

doi:10.1016/S0079-6123(08)61773-2

S100β and serotonin: A possible astrocytic-neuronal link to neuropathology of Alzheimer's disease

E. C. Azmitia, W. S T Griffin, D. R. Marshak, L. J. Van Eldik, P. M. Whitaker-Azmitia

Biology and Genomics

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Abstract

The chapter discusses a possible role for Sl00β and serotonin (5-HT) as an astrocytic (S100β)/ neuronal (serotonin; 5-HT) link to neuropathologies associated with Alzheimer's disease. Sl00β is a protein produced and released from astrocytes in the brain. Extracellular Sl00β can function as a neurotrophic factor to select central and peripheral neurons and a gliotrophic factor, inducing mitosis and morphogenesis of astrocytes. Release of S100β from astrocytes can be stimulated by serotonin acting through 5-HT1, receptors on astrocytes, and S100β functions as a serotonergic neurite extension factor. The abnormal regulation of Sl00β levels or of serotonin-stimulated release of Sl00β in Alzheimer's disease contributes to the cascade of events that with aging lead to neuropathologies. It is also suggested that this astrocytic (S100β)/ neuronal (serotonin) link may contribute to neuropathological changes observed not only in Alzheimer's disease, but also in Down syndrome.

Original language	English (US)
Pages (from-to)	459-473
Number of pages	15
Journal	Progress in Brain Research
Volume	94
Issue number	C
DOIs	https://doi.org/10.1016/S0079-6123(08)61773-2
State	Published - Jan 1 1992

ASJC Scopus subject areas

General Neuroscience

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title = "S100β and serotonin: A possible astrocytic-neuronal link to neuropathology of Alzheimer's disease",

abstract = "The chapter discusses a possible role for Sl00β and serotonin (5-HT) as an astrocytic (S100β)/ neuronal (serotonin; 5-HT) link to neuropathologies associated with Alzheimer's disease. Sl00β is a protein produced and released from astrocytes in the brain. Extracellular Sl00β can function as a neurotrophic factor to select central and peripheral neurons and a gliotrophic factor, inducing mitosis and morphogenesis of astrocytes. Release of S100β from astrocytes can be stimulated by serotonin acting through 5-HT1, receptors on astrocytes, and S100β functions as a serotonergic neurite extension factor. The abnormal regulation of Sl00β levels or of serotonin-stimulated release of Sl00β in Alzheimer's disease contributes to the cascade of events that with aging lead to neuropathologies. It is also suggested that this astrocytic (S100β)/ neuronal (serotonin) link may contribute to neuropathological changes observed not only in Alzheimer's disease, but also in Down syndrome.",

author = "Azmitia, {E. C.} and Griffin, {W. S T} and Marshak, {D. R.} and {Van Eldik}, {L. J.} and Whitaker-Azmitia, {P. M.}",

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AU - Marshak, D. R.

AU - Van Eldik, L. J.

AU - Whitaker-Azmitia, P. M.

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N2 - The chapter discusses a possible role for Sl00β and serotonin (5-HT) as an astrocytic (S100β)/ neuronal (serotonin; 5-HT) link to neuropathologies associated with Alzheimer's disease. Sl00β is a protein produced and released from astrocytes in the brain. Extracellular Sl00β can function as a neurotrophic factor to select central and peripheral neurons and a gliotrophic factor, inducing mitosis and morphogenesis of astrocytes. Release of S100β from astrocytes can be stimulated by serotonin acting through 5-HT1, receptors on astrocytes, and S100β functions as a serotonergic neurite extension factor. The abnormal regulation of Sl00β levels or of serotonin-stimulated release of Sl00β in Alzheimer's disease contributes to the cascade of events that with aging lead to neuropathologies. It is also suggested that this astrocytic (S100β)/ neuronal (serotonin) link may contribute to neuropathological changes observed not only in Alzheimer's disease, but also in Down syndrome.

AB - The chapter discusses a possible role for Sl00β and serotonin (5-HT) as an astrocytic (S100β)/ neuronal (serotonin; 5-HT) link to neuropathologies associated with Alzheimer's disease. Sl00β is a protein produced and released from astrocytes in the brain. Extracellular Sl00β can function as a neurotrophic factor to select central and peripheral neurons and a gliotrophic factor, inducing mitosis and morphogenesis of astrocytes. Release of S100β from astrocytes can be stimulated by serotonin acting through 5-HT1, receptors on astrocytes, and S100β functions as a serotonergic neurite extension factor. The abnormal regulation of Sl00β levels or of serotonin-stimulated release of Sl00β in Alzheimer's disease contributes to the cascade of events that with aging lead to neuropathologies. It is also suggested that this astrocytic (S100β)/ neuronal (serotonin) link may contribute to neuropathological changes observed not only in Alzheimer's disease, but also in Down syndrome.

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S100β and serotonin: A possible astrocytic-neuronal link to neuropathology of Alzheimer's disease

Abstract

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