Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Bengt Fadeel; Cyrill Bussy; Sonia Merino; Ester Vázquez; Emmanuel Flahaut; Florence Mouchet; Lauris Evariste; Laury Gauthier; Antti J. Koivisto; Ulla Vogel; Cristina Martín; Lucia G. Delogu; Tina Buerki-Thurnherr; Peter Wick; Didier Beloin-Saint-Pierre; Roland Hischier; Marco Pelin; Fabio Candotto Carniel; Mauro Tretiach; Fabrizia Cesca; Fabio Benfenati; Denis Scaini; Laura Ballerini; Kostas Kostarelos; Maurizio Prato; Alberto Bianco

doi:10.1021/acsnano.8b04758

Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Bengt Fadeel, Cyrill Bussy, Sonia Merino, Ester Vázquez, Emmanuel Flahaut, Florence Mouchet, Lauris Evariste, Laury Gauthier, Antti J. Koivisto, Ulla Vogel, Cristina Martín, Lucia G. Delogu, Tina Buerki-Thurnherr, Peter Wick, Didier Beloin-Saint-Pierre, Roland Hischier, Marco Pelin, Fabio Candotto Carniel, Mauro Tretiach, Fabrizia CescaFabio Benfenati, Denis Scaini, Laura Ballerini, Kostas Kostarelos, Maurizio Prato, Alberto Bianco

Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

Original language	English (US)
Pages (from-to)	10582-10620
Number of pages	39
Journal	ACS nano
Volume	12
Issue number	11
DOIs	https://doi.org/10.1021/acsnano.8b04758
State	Published - Nov 27 2018

Keywords

carbon nanomaterials
environment
exposure
graphene
hazard
life cycle assessment
safety
toxicity

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/acsnano.8b04758

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Fadeel, B., Bussy, C., Merino, S., Vázquez, E., Flahaut, E., Mouchet, F., Evariste, L., Gauthier, L., Koivisto, A. J., Vogel, U., Martín, C., Delogu, L. G., Buerki-Thurnherr, T., Wick, P., Beloin-Saint-Pierre, D., Hischier, R., Pelin, M., Candotto Carniel, F., Tretiach, M., ... Bianco, A. (2018). Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment. ACS nano, 12(11), 10582-10620. https://doi.org/10.1021/acsnano.8b04758

Fadeel, B, Bussy, C, Merino, S, Vázquez, E, Flahaut, E, Mouchet, F, Evariste, L, Gauthier, L, Koivisto, AJ, Vogel, U, Martín, C, Delogu, LG, Buerki-Thurnherr, T, Wick, P, Beloin-Saint-Pierre, D, Hischier, R, Pelin, M, Candotto Carniel, F, Tretiach, M, Cesca, F, Benfenati, F, Scaini, D, Ballerini, L, Kostarelos, K, Prato, M & Bianco, A 2018, 'Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment', ACS nano, vol. 12, no. 11, pp. 10582-10620. https://doi.org/10.1021/acsnano.8b04758

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title = "Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment",

abstract = "Graphene and its derivatives are heralded as {"}miracle{"} materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.",

keywords = "carbon nanomaterials, environment, exposure, graphene, hazard, life cycle assessment, safety, toxicity",

author = "Bengt Fadeel and Cyrill Bussy and Sonia Merino and Ester V{\'a}zquez and Emmanuel Flahaut and Florence Mouchet and Lauris Evariste and Laury Gauthier and Koivisto, {Antti J.} and Ulla Vogel and Cristina Mart{\'i}n and Delogu, {Lucia G.} and Tina Buerki-Thurnherr and Peter Wick and Didier Beloin-Saint-Pierre and Roland Hischier and Marco Pelin and {Candotto Carniel}, Fabio and Mauro Tretiach and Fabrizia Cesca and Fabio Benfenati and Denis Scaini and Laura Ballerini and Kostas Kostarelos and Maurizio Prato and Alberto Bianco",

note = "Funding Information: The authors are supported by the European Commission through the Graphene Flagship Project (Grant Agreement No. 696656), the JTC 2015 FLAG-ERA project (G-Immunomics), and the FP7-GLADIATOR project (Grant Agreement No. 604000). B.F. is also supported, in part, by the national MISTRA Environmental Nanosafety Program (Sweden). A.B. wishes to thank the French National Research Agency (ANR-15-GRFL-0001-05) and the International Center for Frontier Research in Chemistry (icFRC) for funding. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = nov,

day = "27",

doi = "10.1021/acsnano.8b04758",

language = "English (US)",

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T1 - Safety Assessment of Graphene-Based Materials

T2 - Focus on Human Health and the Environment

AU - Fadeel, Bengt

AU - Bussy, Cyrill

AU - Merino, Sonia

AU - Vázquez, Ester

AU - Flahaut, Emmanuel

AU - Mouchet, Florence

AU - Evariste, Lauris

AU - Gauthier, Laury

AU - Koivisto, Antti J.

AU - Vogel, Ulla

AU - Martín, Cristina

AU - Delogu, Lucia G.

AU - Buerki-Thurnherr, Tina

AU - Wick, Peter

AU - Beloin-Saint-Pierre, Didier

AU - Hischier, Roland

AU - Pelin, Marco

AU - Candotto Carniel, Fabio

AU - Tretiach, Mauro

AU - Cesca, Fabrizia

AU - Benfenati, Fabio

AU - Scaini, Denis

AU - Ballerini, Laura

AU - Kostarelos, Kostas

AU - Prato, Maurizio

AU - Bianco, Alberto

N1 - Funding Information: The authors are supported by the European Commission through the Graphene Flagship Project (Grant Agreement No. 696656), the JTC 2015 FLAG-ERA project (G-Immunomics), and the FP7-GLADIATOR project (Grant Agreement No. 604000). B.F. is also supported, in part, by the national MISTRA Environmental Nanosafety Program (Sweden). A.B. wishes to thank the French National Research Agency (ANR-15-GRFL-0001-05) and the International Center for Frontier Research in Chemistry (icFRC) for funding. Publisher Copyright: © 2018 American Chemical Society.

PY - 2018/11/27

Y1 - 2018/11/27

N2 - Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

AB - Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

KW - carbon nanomaterials

KW - environment

KW - exposure

KW - graphene

KW - hazard

KW - life cycle assessment

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Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Abstract

Keywords

ASJC Scopus subject areas

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