Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Bengt Fadeel, Cyrill Bussy, Sonia Merino, Ester Vázquez, Emmanuel Flahaut, Florence Mouchet, Lauris Evariste, Laury Gauthier, Antti J. Koivisto, Ulla Vogel, Cristina Martín, Lucia G. Delogu, Tina Buerki-Thurnherr, Peter Wick, Didier Beloin-Saint-Pierre, Roland Hischier, Marco Pelin, Fabio Candotto Carniel, Mauro Tretiach, Fabrizia CescaFabio Benfenati, Denis Scaini, Laura Ballerini, Kostas Kostarelos, Maurizio Prato, Alberto Bianco

Research output: Contribution to journalReview articlepeer-review


Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

Original languageEnglish (US)
Pages (from-to)10582-10620
Number of pages39
JournalACS nano
Issue number11
StatePublished - Nov 27 2018


  • carbon nanomaterials
  • environment
  • exposure
  • graphene
  • hazard
  • life cycle assessment
  • safety
  • toxicity

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


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