TY - JOUR
T1 - Sagittal laser optical tomography for imaging of rheumatoid finger joints
AU - Hielscher, Andreas H.
AU - Klose, Alexander D.
AU - Scheel, Alexander K.
AU - Moa-Anderson, Bryte
AU - Backhaus, Marina
AU - Netz, Uwe
AU - Beuthan, Jürgen
PY - 2004/4/7
Y1 - 2004/4/7
N2 - We present a novel optical tomographic imaging system that was designed to determine two-dimensional spatial distribution of optical properties in a sagittal plane through finger joints. The system incorporates a single laser diode and a single silicon photodetector into a scanning device that records spatially resolved light intensities as they are transmitted through a finger. These data are input to a model-based iterative image reconstruction (MOBIIR) scheme, which uses the equation of radiative transfer (ERT) as a forward model for light propagation through tissue. We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images.
AB - We present a novel optical tomographic imaging system that was designed to determine two-dimensional spatial distribution of optical properties in a sagittal plane through finger joints. The system incorporates a single laser diode and a single silicon photodetector into a scanning device that records spatially resolved light intensities as they are transmitted through a finger. These data are input to a model-based iterative image reconstruction (MOBIIR) scheme, which uses the equation of radiative transfer (ERT) as a forward model for light propagation through tissue. We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images.
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U2 - 10.1088/0031-9155/49/7/005
DO - 10.1088/0031-9155/49/7/005
M3 - Article
C2 - 15128195
AN - SCOPUS:1942424830
SN - 0031-9155
VL - 49
SP - 1147
EP - 1163
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 7
ER -