Sagittal laser optical tomography for imaging of rheumatoid finger joints

Andreas H. Hielscher, Alexander D. Klose, Alexander K. Scheel, Bryte Moa-Anderson, Marina Backhaus, Uwe Netz, Jürgen Beuthan

    Research output: Contribution to journalArticlepeer-review


    We present a novel optical tomographic imaging system that was designed to determine two-dimensional spatial distribution of optical properties in a sagittal plane through finger joints. The system incorporates a single laser diode and a single silicon photodetector into a scanning device that records spatially resolved light intensities as they are transmitted through a finger. These data are input to a model-based iterative image reconstruction (MOBIIR) scheme, which uses the equation of radiative transfer (ERT) as a forward model for light propagation through tissue. We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images.

    Original languageEnglish (US)
    Pages (from-to)1147-1163
    Number of pages17
    JournalPhysics in Medicine and Biology
    Issue number7
    StatePublished - Apr 7 2004

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging


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