Salivary biomarkers associated with myocardial necrosis: Results from an alcohol septal ablation model

Joseph D. Foley, J. Darrell Sneed, Steven R. Steinhubl, Justin R. Kolasa, Jeffrey L. Ebersole, Yushun Lin, Richard J. Kryscio, John T. McDevitt, Charles L. Campbell, Craig S. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P <.01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P <.02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P <.001). Conclusions: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.

Original languageEnglish (US)
Pages (from-to)616-623
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume114
Issue number5
DOIs
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

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