TY - JOUR
T1 - Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study
AU - Mulligan, Roseann
AU - Navazesh, Mahvash
AU - Komaroff, Eugene
AU - Greenspan, Deborah
AU - Redford, Maryann
AU - Alves, Mario
AU - Phelan, Joan
N1 - Funding Information:
Statistical and Clinical Coordinating Center, 1995-1998: New England Research Institutes, Watertown, Mass (Susan Barkan, PhD; Leslie Kalish, ScD; Sonja McKinlay PhD; Irene Doherty, BS; Kirstin Nelson, MS; Eugene Komaroff, PhD). The WIHS is funded by the National Institute of Allergy and Infectious Diseases, with supplemental funding from the National Cancer Institute, the National Institute of Child Health & Human Development, The National Institute on Drug Abuse, the National Institute of Dental and Craniofacial Research, the Agency for Health Care Policy and Research, and the Centers for Disease Control and Prevention. U01-AI-35004, U01-AI-31834, U01-AI-34994, AI-34989, U01-HD-32632 (NICHD), U01-AI-34993, U01-AI-42590.
PY - 2000
Y1 - 2000
N2 - Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.
AB - Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.
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U2 - 10.1067/moe.2000.105328
DO - 10.1067/moe.2000.105328
M3 - Article
C2 - 10846124
AN - SCOPUS:0034199951
SN - 1079-2104
VL - 89
SP - 702
EP - 709
JO - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
IS - 6
ER -