Scalable simulation of realistic volume fraction red blood cell flows through vascular networks

Libin Lu, Matthew J. Morse, Abtin Rahimian, Georg Stadler, Denis Zorin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable platform for the simulation of red blood cell (RBC) flows through complex capillaries by modeling the physical system as a viscous fluid with immersed deformable particles. We describe a parallel boundary integral equation solver for general elliptic partial differential equations, which we apply to Stokes flow through blood vessels. We also detail a parallel collision avoiding algorithm to ensure RBCs and the blood vessel remain contact-free. We have scaled our code on Stampede2 at the Texas Advanced Computing Center up to 34,816 cores. Our largest simulation enforces a contact-free state between four billion surface elements and solves for three billion degrees of freedom on one million RBCs and a blood vessel composed from two million patches.

Original languageEnglish (US)
Title of host publicationProceedings of SC 2019
Subtitle of host publicationThe International Conference for High Performance Computing, Networking, Storage and Analysis
PublisherIEEE Computer Society
ISBN (Electronic)9781450362290
DOIs
StatePublished - Nov 17 2019
Event2019 International Conference for High Performance Computing, Networking, Storage and Analysis, SC 2019 - Denver, United States
Duration: Nov 17 2019Nov 22 2019

Publication series

NameInternational Conference for High Performance Computing, Networking, Storage and Analysis, SC
ISSN (Print)2167-4329
ISSN (Electronic)2167-4337

Conference

Conference2019 International Conference for High Performance Computing, Networking, Storage and Analysis, SC 2019
CountryUnited States
CityDenver
Period11/17/1911/22/19

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications
  • Hardware and Architecture
  • Software

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  • Cite this

    Lu, L., Morse, M. J., Rahimian, A., Stadler, G., & Zorin, D. (2019). Scalable simulation of realistic volume fraction red blood cell flows through vascular networks. In Proceedings of SC 2019: The International Conference for High Performance Computing, Networking, Storage and Analysis [a6] (International Conference for High Performance Computing, Networking, Storage and Analysis, SC). IEEE Computer Society. https://doi.org/10.1145/3295500.3356203