Scale-up study of high osmotic pressure chromatography for separation of poly(ε-caprolactone)

Dean Lee, Iwao Teraoka

Research output: Contribution to journalArticlepeer-review


Methods to prepare fractions of poly(ε-caprolactone) with a narrow molecular mass distribution in large quantities have been examined using high osmotic pressure chromatography under the theta condition. Effects of column dimension and coupling columns in series on the separation resolution were studied. We found that use of a thicker column can improve the resolution if adverse effects of viscous fingering are avoided. We also demonstrated that coupling the columns results in a better separation if the second column does not adsorb high-molecular-mass components purified in the first column.

Original languageEnglish (US)
Pages (from-to)71-83
Number of pages13
JournalJournal of Chromatography A
Issue number1-2
StatePublished - May 9 2003


  • High osmotic pressure chromatography
  • Poly(ε-caprolactone)
  • Preparative chromatography
  • Theta solvent

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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