Abstract
A chemical exchange saturation transfer (CEST) experiment can be performed in an ultrafast fashion if a gradient field is applied simultaneously with the saturation pulse. This approach has been demonstrated for studying dia- and para-magnetic CEST agents, hyperpolarized Xe gas and in vivo spectroscopy. In this study we present a simple method for the simultaneous screening of multiple samples. Furthermore, by interleaving a number of saturation and readout periods within the TR, a series of images with different saturation times can be acquired, allowing for the quantification of exchange rates using the variable saturation time (QUEST) approach in a much accelerated fashion, thus enabling high throughput screening of CEST contrast agents.
Original language | English (US) |
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Pages (from-to) | 224-229 |
Number of pages | 6 |
Journal | Journal of Magnetic Resonance |
Volume | 265 |
DOIs | |
State | Published - Apr 1 2016 |
Keywords
- CEST
- Contrast agent
- MRI
- Ultrafast spectroscopy
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Nuclear and High Energy Physics
- Condensed Matter Physics