TY - JOUR
T1 - Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia
AU - Ross, Kharah M.
AU - Baer, Rebecca J.
AU - Ryckman, Kelli
AU - Feuer, Sky K.
AU - Bandoli, Gretchen
AU - Chambers, Christina
AU - Flowers, Elena
AU - Liang, Liang
AU - Oltman, Scott
AU - Dunkel Schetter, Christine
AU - Jelliffe-Pawlowski, Laura
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Objective: Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia. Study design: A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios. Results: Higher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia. Conclusions: Among women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.
AB - Objective: Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia. Study design: A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios. Results: Higher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia. Conclusions: Among women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.
UR - http://www.scopus.com/inward/record.url?scp=85058059764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058059764&partnerID=8YFLogxK
U2 - 10.1038/s41372-018-0275-8
DO - 10.1038/s41372-018-0275-8
M3 - Article
C2 - 30518800
AN - SCOPUS:85058059764
SN - 0743-8346
VL - 39
SP - 314
EP - 320
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 2
ER -