Selective Cleavage of Lignin Model Compounds via a Reverse Biosynthesis Mechanism

Sang Mi Suh, Subramanian Jambu, Mason T. Chin, Tianning Diao

Research output: Contribution to journalArticlepeer-review


Selective depolymerization of lignin remains a significant challenge in biomass conversion. The biosynthesis of lignin involves the polymerization of monolignol building blocks through oxidative radical coupling reactions. A strategy for lignin degradation leverages photoredox deoxygenative radical formation to trigger reverse biosynthesis, which cleaves model compounds of the β-O-4 and β-5-β-O-4 linkages to produce monolignols, precursors to flavoring compounds. This mild method preserves important oxygen functionality and serves as a platform for achieving selective lignin depolymerization.

Original languageEnglish (US)
Pages (from-to)4792-4796
Number of pages5
JournalOrganic Letters
Issue number26
StatePublished - Jul 7 2023

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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