Selective effect of inhibitors on inner mitochondrial membrane channels

Yuri N. Antonenko, Kathleen W. Kinnally, Sean Perini, Henry Tedeschi

Research output: Contribution to journalArticle

Abstract

The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalFEBS Letters
Volume285
Issue number1
DOIs
StatePublished - Jul 8 1991

Keywords

  • Inner mitochondrial membrane
  • Mitochondrial channel
  • Patch-clamp
  • Pharmacology

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Antonenko, Y. N., Kinnally, K. W., Perini, S., & Tedeschi, H. (1991). Selective effect of inhibitors on inner mitochondrial membrane channels. FEBS Letters, 285(1), 89-93. https://doi.org/10.1016/0014-5793(91)80731-H