Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles

F. Benyettou, H. Fahs, R. Elkharrag, R. A. Bilbeisi, B. Asma, Rachid Rezqui, L. Motte, Mazin Magzoub, J. Brandel, J. C. Olsen, Fabio Piano, Kristin Gunsalus, C. Platas-Iglesias, Ali Trabolsi

Research output: Contribution to journalArticle

Abstract

Cucurbit[7]uril-modified iron-oxide nanoparticles (CB[7]NPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system. Dox was found to interact with the carbonyl-rich rims of the CB[7] macrocycles adsorbed on the surface of the nanoparticles. The Dox-loaded nanoparticles (Dox@CB[7]NPs) were stable at room temperature and physiological pH and released their Dox cargo under acidic conditions, in the presence of glutathione, or with heating. Dox@CB[7]NPs reduced the viability of HeLa and three other cancer-derived cell lines in vitro at lower IC50 than free Dox. They were also nontoxic to C. elegans. The sensitivity of HeLa cells to Dox@CB[7]NPs was enhanced when the temperature was elevated by application of an alternating magnetic field. Thus, Dox@CB[7]NPs show promise as agents for the intracellular delivery of Dox to cancer cells, for the selective and controlled release of the drug, and, more generally, as a possible means of combining chemotherapeutic and hyperthermic treatment modalities.

Original languageEnglish (US)
Pages (from-to)23827-23834
Number of pages8
JournalRSC Advances
Volume7
Issue number38
DOIs
StatePublished - 2017

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Iron oxides
Doxorubicin
Cells
Nanoparticles
Glutathione
Magnetic fields
Heating
Temperature
Pharmaceutical Preparations
ferric oxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R. A., Asma, B., Rezqui, R., ... Trabolsi, A. (2017). Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Advances, 7(38), 23827-23834. https://doi.org/10.1039/c7ra02693e

Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. / Benyettou, F.; Fahs, H.; Elkharrag, R.; Bilbeisi, R. A.; Asma, B.; Rezqui, Rachid; Motte, L.; Magzoub, Mazin; Brandel, J.; Olsen, J. C.; Piano, Fabio; Gunsalus, Kristin; Platas-Iglesias, C.; Trabolsi, Ali.

In: RSC Advances, Vol. 7, No. 38, 2017, p. 23827-23834.

Research output: Contribution to journalArticle

Benyettou, F, Fahs, H, Elkharrag, R, Bilbeisi, RA, Asma, B, Rezqui, R, Motte, L, Magzoub, M, Brandel, J, Olsen, JC, Piano, F, Gunsalus, K, Platas-Iglesias, C & Trabolsi, A 2017, 'Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles' RSC Advances, vol. 7, no. 38, pp. 23827-23834. https://doi.org/10.1039/c7ra02693e
Benyettou, F. ; Fahs, H. ; Elkharrag, R. ; Bilbeisi, R. A. ; Asma, B. ; Rezqui, Rachid ; Motte, L. ; Magzoub, Mazin ; Brandel, J. ; Olsen, J. C. ; Piano, Fabio ; Gunsalus, Kristin ; Platas-Iglesias, C. ; Trabolsi, Ali. / Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. In: RSC Advances. 2017 ; Vol. 7, No. 38. pp. 23827-23834.
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