Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery

Jongjin Jung, Aniruddh Solanki, Kevin A. Memoli, Ken Ichiro Kamei, Hiyun Kim, Michael A. Drahl, Lawrence J. Williams, Hsian Rong Tseng, Kibum Lee

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) More than one Job: Quantum dots (QDs) conjugated with thiol-modified small Interfering RNA (siRNA) were functlonalized with thiol-modlfied RGD and HIV-Tat peptides. These multifunctional QDs were used for the targeted delivery and tracking of siRNA molecules for the knockdown of the EGFRvIII gene, which led to the down-regulation of the PI3K-Akt signaling pathway and the apoptosis of malignant brain cancer cells.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number1
DOIs
StatePublished - Jan 4 2010

Keywords

  • Antitumor agents
  • Gene knockdown
  • Nanoparticles
  • Nonviral sirna delivery
  • Target-specific delivery

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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