Abstract
A mild and general set of metalation procedures for the functionalization of unsymmetrical azobenzenes using a commercially available continuous-flow setup is reported. The metalations proceed with TMPLi under convenient conditions (0 °C, 20 s), and various classes of electrophiles can be used. With sensitive substrates, an in situ trapping metalation in which TMPLi is added to a mixture of the azobenzene and ZnCl2 or MgCl2·LiCl was very effective for achieving high yields.
Original language | English (US) |
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Pages (from-to) | 1666-1669 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 7 |
DOIs | |
State | Published - Apr 7 2017 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry