Abstract
Come together: A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)-rich oligodeoxynucleotide scaffold forms a hydrogen-bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.
Original language | English (US) |
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Pages (from-to) | 2749-2751 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 15 |
DOIs | |
State | Published - Mar 30 2009 |
Keywords
- DNA structures
- G-quadruplexes
- Helical structures
- Protein design
- Self-assembly
ASJC Scopus subject areas
- Catalysis
- General Chemistry