Self-assembly of a four-helix bundle on a DNA quadruplex

Brooke A. Rosenzweig, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


Come together: A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)-rich oligodeoxynucleotide scaffold forms a hydrogen-bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.

Original languageEnglish (US)
Pages (from-to)2749-2751
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number15
StatePublished - Mar 30 2009


  • DNA structures
  • G-quadruplexes
  • Helical structures
  • Protein design
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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