Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation

Xiushuang Yuan; Linhai Jiang; Weike Chen; Bo Song; Wei Chen; Xiaobing Zuo; Xiankai Sun; Xiaopeng Li; Kent Kirshenbaum; Shizhong Luo; He Dong

doi:10.1039/d0cc02066d

Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation

Xiushuang Yuan, Linhai Jiang, Weike Chen, Bo Song, Wei Chen, Xiaobing Zuo, Xiankai Sun, Xiaopeng Li, Kent Kirshenbaum, Shizhong Luo, He Dong

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.

Original language	English (US)
Pages (from-to)	7128-7131
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	52
DOIs	https://doi.org/10.1039/d0cc02066d
State	Published - Jul 4 2020

Keywords

Amino Acid Sequence
Biological Transport
Cell Line, Tumor
Collagen/chemistry
Humans
Ligands
Molecular Dynamics Simulation
Nanofibers/chemistry
Optical Imaging
Peptides/chemistry
Protein Conformation
Protein Multimerization
Receptors, Cell Surface/metabolism

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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10.1039/d0cc02066d

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title = "Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation",

abstract = "This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.",

keywords = "Amino Acid Sequence, Biological Transport, Cell Line, Tumor, Collagen/chemistry, Humans, Ligands, Molecular Dynamics Simulation, Nanofibers/chemistry, Optical Imaging, Peptides/chemistry, Protein Conformation, Protein Multimerization, Receptors, Cell Surface/metabolism",

author = "Xiushuang Yuan and Linhai Jiang and Weike Chen and Bo Song and Wei Chen and Xiaobing Zuo and Xiankai Sun and Xiaopeng Li and Kent Kirshenbaum and Shizhong Luo and He Dong",

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year = "2020",

month = jul,

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doi = "10.1039/d0cc02066d",

language = "English (US)",

volume = "56",

pages = "7128--7131",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation

AU - Yuan, Xiushuang

AU - Jiang, Linhai

AU - Chen, Weike

AU - Song, Bo

AU - Chen, Wei

AU - Zuo, Xiaobing

AU - Sun, Xiankai

AU - Li, Xiaopeng

AU - Kirshenbaum, Kent

AU - Luo, Shizhong

AU - Dong, He

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/7/4

Y1 - 2020/7/4

N2 - This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.

AB - This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.

KW - Amino Acid Sequence

KW - Biological Transport

KW - Cell Line, Tumor

KW - Collagen/chemistry

KW - Humans

KW - Ligands

KW - Molecular Dynamics Simulation

KW - Nanofibers/chemistry

KW - Optical Imaging

KW - Peptides/chemistry

KW - Protein Conformation

KW - Protein Multimerization

KW - Receptors, Cell Surface/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85087469155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85087469155&partnerID=8YFLogxK

U2 - 10.1039/d0cc02066d

DO - 10.1039/d0cc02066d

M3 - Article

C2 - 32458863

AN - SCOPUS:85087469155

SN - 1359-7345

VL - 56

SP - 7128

EP - 7131

JO - Chemical Communications

JF - Chemical Communications

IS - 52

ER -

Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation

Abstract

Keywords

ASJC Scopus subject areas

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