Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi

Research output: Contribution to journalArticle

Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Original languageEnglish (US)
Pages (from-to)8876-8879
Number of pages4
JournalChemical Communications
Volume55
Issue number60
DOIs
StatePublished - Aug 4 2019

Keywords

  • Antineoplastic Agents/chemistry
  • Calixarenes/chemical synthesis
  • Camptothecin/chemistry
  • Drug Carriers/chemical synthesis
  • Drug Liberation
  • Humans
  • Hydrogen-Ion Concentration
  • MCF-7 Cells
  • Nanocapsules/chemistry
  • Phenols/chemical synthesis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis

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