Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty; Tina Skorjanc; Mark Anthony Olson; Ali Trabolsi

doi:10.1039/c9cc02214g

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Original language	English (US)
Pages (from-to)	8876-8879
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	60
DOIs	https://doi.org/10.1039/c9cc02214g
State	Published - Aug 4 2019

Keywords

Antineoplastic Agents/chemistry
Calixarenes/chemical synthesis
Camptothecin/chemistry
Drug Carriers/chemical synthesis
Drug Liberation
Humans
Hydrogen-Ion Concentration
MCF-7 Cells
Nanocapsules/chemistry
Phenols/chemical synthesis

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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10.1039/c9cc02214g

Cite this

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title = "Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery",

abstract = "Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.",

keywords = "Antineoplastic Agents/chemistry, Calixarenes/chemical synthesis, Camptothecin/chemistry, Drug Carriers/chemical synthesis, Drug Liberation, Humans, Hydrogen-Ion Concentration, MCF-7 Cells, Nanocapsules/chemistry, Phenols/chemical synthesis",

author = "Dinesh Shetty and Tina Skorjanc and Olson, {Mark Anthony} and Ali Trabolsi",

note = "Funding Information: This work was supported by New York University Abu Dhabi (NYUAD). We thank NYUAD and the Core Technology Platforms for their generous support for the research program. The authors thank Ms Jumaanah Elhashemi for 3D cartoons. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

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doi = "10.1039/c9cc02214g",

language = "English (US)",

volume = "55",

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journal = "Chemical Communications",

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AU - Shetty, Dinesh

AU - Skorjanc, Tina

AU - Olson, Mark Anthony

AU - Trabolsi, Ali

N1 - Funding Information: This work was supported by New York University Abu Dhabi (NYUAD). We thank NYUAD and the Core Technology Platforms for their generous support for the research program. The authors thank Ms Jumaanah Elhashemi for 3D cartoons. Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019/8/4

Y1 - 2019/8/4

N2 - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

AB - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

KW - Antineoplastic Agents/chemistry

KW - Calixarenes/chemical synthesis

KW - Camptothecin/chemistry

KW - Drug Carriers/chemical synthesis

KW - Drug Liberation

KW - Humans

KW - Hydrogen-Ion Concentration

KW - MCF-7 Cells

KW - Nanocapsules/chemistry

KW - Phenols/chemical synthesis

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JO - Chemical Communications

JF - Chemical Communications

IS - 60

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Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Abstract

Keywords

ASJC Scopus subject areas

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