Abstract
Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.
Original language | English (US) |
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Pages (from-to) | 8876-8879 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 60 |
DOIs | |
State | Published - Aug 4 2019 |
Keywords
- Antineoplastic Agents/chemistry
- Calixarenes/chemical synthesis
- Camptothecin/chemistry
- Drug Carriers/chemical synthesis
- Drug Liberation
- Humans
- Hydrogen-Ion Concentration
- MCF-7 Cells
- Nanocapsules/chemistry
- Phenols/chemical synthesis
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Chemistry(all)
- Catalysis