Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study

Anna Bershteyn; Angela M. Dahl; Tracy Q. Dong; Meagan E. Deming; Connie L. Celum; Helen Y. Chu; Angelica C. Kottkamp; Alexander L. Greninger; Risa M. Hoffman; Keith R. Jerome; Christine M. Johnston; Patricia J. Kissinger; Raphael J. Landovitz; Miriam K. Laufer; Alfred Luk; Kathleen M. Neuzil; Michael K. Paasche-Orlow; Robert A. Pitts; Mark D. Schwartz; Helen C. Stankiewicz Karita; Lorna E. Thorpe; Anna Wald; Crystal Y. Zheng; Mark H. Wener; Ruanne V. Barnabas; Elizabeth R. Brown

doi:10.1093/cid/ciac129

Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study

Anna Bershteyn, Angela M. Dahl, Tracy Q. Dong, Meagan E. Deming, Connie L. Celum, Helen Y. Chu, Angelica C. Kottkamp, Alexander L. Greninger, Risa M. Hoffman, Keith R. Jerome, Christine M. Johnston, Patricia J. Kissinger, Raphael J. Landovitz, Miriam K. Laufer, Alfred Luk, Kathleen M. Neuzil, Michael K. Paasche-Orlow, Robert A. Pitts, Mark D. Schwartz, Helen C. Stankiewicz KaritaLorna E. Thorpe, Anna Wald, Crystal Y. Zheng, Mark H. Wener, Ruanne V. Barnabas, Elizabeth R. Brown

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Abstract

Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%-66.7%) to 31.5% (95% CI, 25.7%-38.0%) but increased specificity from 77.5% (95% CI, 75.3%-79.5%) to 93.8% (95% CI, 92.7%-94.8%).

Original language	English (US)
Pages (from-to)	E1180-E1183
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciac129
State	Published - Jul 1 2022

Keywords

COVID-19
SARS-CoV-2
screening
severity
symptoms

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciac129

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Bershteyn, A., Dahl, A. M., Dong, T. Q., Deming, M. E., Celum, C. L., Chu, H. Y., Kottkamp, A. C., Greninger, A. L., Hoffman, R. M., Jerome, K. R., Johnston, C. M., Kissinger, P. J., Landovitz, R. J., Laufer, M. K., Luk, A., Neuzil, K. M., Paasche-Orlow, M. K., Pitts, R. A., Schwartz, M. D., ... Brown, E. R. (2022). Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study. Clinical Infectious Diseases, 75(1), E1180-E1183. https://doi.org/10.1093/cid/ciac129

Bershteyn, A, Dahl, AM, Dong, TQ, Deming, ME, Celum, CL, Chu, HY, Kottkamp, AC, Greninger, AL, Hoffman, RM, Jerome, KR, Johnston, CM, Kissinger, PJ, Landovitz, RJ, Laufer, MK, Luk, A, Neuzil, KM, Paasche-Orlow, MK, Pitts, RA, Schwartz, MD, Stankiewicz Karita, HC, Thorpe, LE, Wald, A, Zheng, CY, Wener, MH, Barnabas, RV & Brown, ER 2022, 'Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study', Clinical Infectious Diseases, vol. 75, no. 1, pp. E1180-E1183. https://doi.org/10.1093/cid/ciac129

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abstract = "Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%-66.7%) to 31.5% (95% CI, 25.7%-38.0%) but increased specificity from 77.5% (95% CI, 75.3%-79.5%) to 93.8% (95% CI, 92.7%-94.8%).",

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author = "Anna Bershteyn and Dahl, {Angela M.} and Dong, {Tracy Q.} and Deming, {Meagan E.} and Celum, {Connie L.} and Chu, {Helen Y.} and Kottkamp, {Angelica C.} and Greninger, {Alexander L.} and Hoffman, {Risa M.} and Jerome, {Keith R.} and Johnston, {Christine M.} and Kissinger, {Patricia J.} and Landovitz, {Raphael J.} and Laufer, {Miriam K.} and Alfred Luk and Neuzil, {Kathleen M.} and Paasche-Orlow, {Michael K.} and Pitts, {Robert A.} and Schwartz, {Mark D.} and {Stankiewicz Karita}, {Helen C.} and Thorpe, {Lorna E.} and Anna Wald and Zheng, {Crystal Y.} and Wener, {Mark H.} and Barnabas, {Ruanne V.} and Brown, {Elizabeth R.}",

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doi = "10.1093/cid/ciac129",

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AU - Deming, Meagan E.

AU - Celum, Connie L.

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AU - Kottkamp, Angelica C.

AU - Greninger, Alexander L.

AU - Hoffman, Risa M.

AU - Jerome, Keith R.

AU - Johnston, Christine M.

AU - Kissinger, Patricia J.

AU - Landovitz, Raphael J.

AU - Laufer, Miriam K.

AU - Luk, Alfred

AU - Neuzil, Kathleen M.

AU - Paasche-Orlow, Michael K.

AU - Pitts, Robert A.

AU - Schwartz, Mark D.

AU - Stankiewicz Karita, Helen C.

AU - Thorpe, Lorna E.

AU - Wald, Anna

AU - Zheng, Crystal Y.

AU - Wener, Mark H.

AU - Barnabas, Ruanne V.

AU - Brown, Elizabeth R.

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AB - Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%-66.7%) to 31.5% (95% CI, 25.7%-38.0%) but increased specificity from 77.5% (95% CI, 75.3%-79.5%) to 93.8% (95% CI, 92.7%-94.8%).

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Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study

Abstract

Keywords

ASJC Scopus subject areas

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