Sendai virus infection of mice with protein malnutrition

V. Pena-Cruz, C. S. Reiss, K. McIntosh

Research output: Contribution to journalArticlepeer-review


Sendai virus pneumonia was produced in BALB/c mice fed protein-deficient diets in an effort to understand the severity of viral pneumonia in infants in developing countries. Animals on the deficient diet became clinically malnourished, and some aspects of cellular immunity were altered. In protein-deprived animals, the 50% lethal dose of intranasally administered Sendai virus was over 1,000-fold lower, pulmonary virus titers were higher, the infection was prolonged, and lung infection was established at a lower inoculum than in normal animals.

Original languageEnglish (US)
Pages (from-to)3541-3544
Number of pages4
JournalJournal of virology
Issue number8
StatePublished - 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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