Sensitisation of TRPV4 by PAR₂ is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Medicine & Life Sciences

• PAR-2 Receptor 100%
• Leukocyte Elastase 89%
• Oocytes 19%
• rho-Associated Kinases 19%
• N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide 19%
• seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide 9%
• Artificial Receptors 8%
• Ethane 7%
• Calcium Chelating Agents 7%
• 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 7%
• Pancreatic Elastase 6%
• Inflammation 6%
• Xenopus laevis 6%
• Trypsin 5%
• Cations 5%
• Peptide Hydrolases 4%
• Acids 4%

Chemical Compounds

• Sensitization 73%
• Calcium(0) 53%
• Rho Kinase Inhibitor 9%
• BAPTA 8%
• Conductance 4%
• Trypsin 4%
• Acid 1%