Sensitivity analysis for frequency-domain optical tomography of small tissue volumes

Xuejun Gu, Uwe J. Netz, Kui Ren, Jürgen Beuthan, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We perform numerical and experimental sensitivity analyses for the imaging problem in small-volume optical tomography with the frequency-domain equation of radiative transfer as light propagation model. Varying the optical properties, tissue geometries, and contrast, we show that source modulation frequencies in the range of 300-600MHz yield maximal signal-to-noise ratios and therefore maximal sensitivity to tissue inhomogeneities.

Original languageEnglish (US)
Title of host publicationBiomedical Topical Meeting, BIO 2006
PublisherOptical Society of America
ISBN (Print)1557528071, 9781557528070
StatePublished - 2006
EventBiomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States
Duration: Mar 19 2006Mar 19 2006

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceBiomedical Topical Meeting, BIO 2006
Country/TerritoryUnited States
CityFort Lauderdale, FL

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics


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