Sensitivity analysis for small imaging domains using the frequency-domain transport equation

Xuejun Gu, Kui Ren, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.

    Original languageEnglish (US)
    Title of host publicationDiffuse Optical Imaging of Tissue
    PublisherSPIE
    ISBN (Print)0819467731, 9780819467737
    DOIs
    StatePublished - 2007
    EventDiffuse Optical Imaging of Tissue - Munich, Germany
    Duration: Jun 19 2007Jun 21 2007

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume6629
    ISSN (Print)1605-7422

    Conference

    ConferenceDiffuse Optical Imaging of Tissue
    CountryGermany
    CityMunich
    Period6/19/076/21/07

    Keywords

    • Equation of radiative transfer
    • Finite volume method
    • Optical tomography
    • Signal-to-noise

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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