Sensitivity analysis for small imaging domains using the frequency-domain transport equation

Xuejun Gu, Kui Ren, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.

Original languageEnglish (US)
Title of host publicationDiffuse Optical Imaging of Tissue
ISBN (Print)0819467731, 9780819467737
StatePublished - 2007
EventDiffuse Optical Imaging of Tissue - Munich, Germany
Duration: Jun 19 2007Jun 21 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceDiffuse Optical Imaging of Tissue


  • Equation of radiative transfer
  • Finite volume method
  • Optical tomography
  • Signal-to-noise

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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