Sensitization in Aplysia: Restoration of transmission in synapses inactivated by long-term habituation

Thomas Carew, Vincent F. Castellucci, Eric R. Kandel

Research output: Contribution to journalArticle

Abstract

Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.

Original languageEnglish (US)
Pages (from-to)417-419
Number of pages3
JournalScience
Volume205
Issue number4404
DOIs
StatePublished - 1979

ASJC Scopus subject areas

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