TY - JOUR
T1 - Sensitization in Aplysia
T2 - Restoration of transmission in synapses inactivated by long-term habituation
AU - Carew, Thomas
AU - Castellucci, Vincent F.
AU - Kandel, Eric R.
PY - 1979
Y1 - 1979
N2 - Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.
AB - Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.
UR - http://www.scopus.com/inward/record.url?scp=0018650103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018650103&partnerID=8YFLogxK
U2 - 10.1126/science.451611
DO - 10.1126/science.451611
M3 - Article
C2 - 451611
AN - SCOPUS:0018650103
SN - 0036-8075
VL - 205
SP - 417
EP - 419
JO - Science
JF - Science
IS - 4404
ER -